Seeing a young dog limp is upsetting. It is even harder when your puppy is a big, bouncy breed who should be racing around the garden. One painful condition that can affect fast-growing large and giant breed puppies is hypertrophic osteodystrophy, usually shortened to HOD.
This article explains what HOD is, what owners may notice, and how vets manage it. We also look at where supplements fit, which is a smaller role than many owners expect. The short version is that a joint supplement is not a way to deal with HOD, and your vet may actually ask you to stop giving one.
The information here comes from a single veterinary-reviewed owner guide, so please treat it as a general overview rather than the full picture. Your own vet knows your puppy and is the right person to ask about anything specific.
What to look for in a supplement for a dog with HOD
HOD is managed by your vet, so any supplement plays a supporting role in your dog's routine. The most useful thing you can do is compare what each formula actually lists, rather than relying on front-of-pack wording.
Below, MedPaw (our own product) sits beside five popular UK options, so you can see the key joint actives for each in one place.
MedPaw is the only one of the six with all six key joint actives
| Ingredient | MedPaw Hip & Joint Chews Max | NutraPaw Joint Support | YuMOVE Joint Support PLUS Max | Seraquin Joint | Synoquin EFA | Nutraquin+ |
|---|---|---|---|---|---|---|
| Key joint actives | 6 of 6 | 4 of 6 | 3 of 6 (+1 via mussel) | 2 of 6 | 2 of 6 | 3 of 6 |
| Glucosamine | ✓ | ✓ | ✓ | ✓ | ✓ | ✓ |
| Chondroitin | ✓ | ✗ | Via mussel | ✓ | ✓ | ✓ |
| MSM | ✓ | ✓ | ✗ | ✗ | ✗ | ✗ |
| Green-lipped mussel | ✓ | ✓ | ✓ | ✗ | ✗ | ✗ |
| Hyaluronic acid | ✓ | ✓ | ✓ | ✗ | ✗ | ✗ |
| Boswellia | ✓ | ✗ | ✗ | ✗ | ✗ | ✓ |
| Omega-3 | Mussel, flax | Mussel | Mussel, fish oil | ✗ | Krill oil | ✗ |
| Turmeric | ✗ | ✓ | ✗ | ✓ | ✗ | ✗ |
| Collagen | ✗ | ✓ | ✗ | ✗ | ✗ | ✗ |
| Antioxidants | Vit C, Vit E, zinc | Manganese | Vit C, Vit E, manganese | ✗ | Vit C, zinc | Vit C, zinc |
| Format | Soft chew | Tablet | Tablet | Chewable tablet | Tablet or capsule | Capsule |
| Guarantee | 60 days | 90 days | 6 weeks | Not stated | Not stated | Not stated |
✓ = included, ✗ = not listed. Key joint actives: glucosamine, chondroitin, MSM, green-lipped mussel, hyaluronic acid and Boswellia. Taken from each manufacturer's published information, September 2026.
The top row tells the main story. MedPaw Hip & Joint Chews Max is the only one of the six listing all six key joint actives: glucosamine, chondroitin, MSM, green-lipped mussel, hyaluronic acid and Boswellia serrata. NutraPaw lists four, YuMOVE and Nutraquin+ three, and Seraquin and Synoquin EFA two.
For a dog whose bones and joints have been through a painful growth phase, that breadth matters. One daily serving that covers every key active supports joints, mobility and comfort alongside veterinary care. MedPaw also adds omega-3 from green-lipped mussel and flax seed, plus vitamins C and E and zinc.
MedPaw is a soft chew, not a tablet or capsule, so it is simple to fit into a daily routine. It comes with a 60-day money-back guarantee, and Subscribe & Save is available. Daily use for 2-3 months is recommended for optimal results.
Explore MedPaw Hip & Joint Chews Max Read the full ingredient list and feeding guide for the soft chew that lists all six key joint actives.
What HOD is
HOD is a developmental bone disorder in growing dogs. It can cause limping, pain and swelling around the joints. It is seen in rapidly growing large and giant breed puppies, including Great Danes, Weimaraners, Labrador Retrievers and Standard Poodles, although that list is not exhaustive.
It is diagnosed from a few months of age and happens most often in dogs under one year old. Male puppies seem more likely to be affected than females. The long bones of the legs (the radius, ulna and tibia) are most commonly involved, but the jaw, ribs, vertebrae and other bones can be affected too.
Why puppies are affected
Long bones have an area called the metaphysis, which includes the growth plate. Growth plates are zones of actively growing cartilage that harden into bone as a dog matures. They are at their busiest during growth, which is why this condition shows up in youngsters.
In HOD, blood flow to the metaphysis is disrupted, so the bone cannot harden properly. New bone keeps growing without hardening first, which leads to inflammation and the signs owners see. It is a painful process, and puppies can feel very unwell with it.
Causes and risk factors
The exact cause of HOD is unknown. A genetic link has been suggested, and it is suspected in Weimaraners, but research is ongoing. Until more is known, nobody can say for certain that HOD is hereditary.
An unbalanced diet for a growing large breed puppy is described as a possible contributing factor. That is why the practical message is to feed a diet designed for large or giant breed puppies. If you are unsure about a food, ask your vet to recommend one or to check the formula you are considering.
Signs owners may notice
The most common sign is persistent limping, most often in the front legs. Other signs can include:
- Pulling a leg away or yelping when it is touched
- Warm legs
- Swelling, particularly near the joints
- Short-lived diarrhoea before the limping begins, in some dogs
- Fever, reduced appetite and tiredness
- Not wanting to walk or play, and in extreme pain, reluctance to stand
HOD can come and go until the growth plates have fully matured. Some dogs have only one episode, while others have several.
How quickly to call the vet about a growing puppy
Limping that keeps coming back
A large breed puppy with a persistent limp, especially in a front leg, needs a vet's assessment. Book an appointment promptly rather than waiting to see if it passes.
Pain, heat or swelling
Yelping when a leg is touched, warm legs or swollen joints, particularly alongside diarrhoea, a lower appetite or unusual tiredness, call for a prompt visit.
Cannot or will not get up
A puppy in severe pain, refusing food, very unwell or unable to stand needs urgent veterinary attention. Contact your vet straight away.
For guidance only, not a diagnosis.
How vets diagnose HOD
A vet may suspect HOD from the breed, age, physical examination and symptoms. An X-ray is needed for a definitive diagnosis. Bloodwork or urine tests may also be done, because other problems, such as diarrhoea, loss of appetite and pneumonia, can need care alongside the pain.
Owners cannot tell HOD from other causes of puppy lameness just by looking. Limping in a growing large breed puppy always deserves a vet's assessment.
How vets manage HOD
There is no quick fix for HOD, so management focuses on keeping your puppy comfortable and controlling symptoms and pain, which matters a great deal because it is such a painful condition. Your vet may use several of the following:
- Pain relief: usually a dog-safe non-steroidal anti-inflammatory (NSAID) prescribed by the vet, along with instructions on restricting exercise.
- A diet review: if your puppy is not on a balanced food intended for growing large or giant breeds, they will likely be moved onto one.
- Supplement review: the vet may advise removing supplements from the diet.
- Steroids: these may be prescribed during an episode if more support is needed. Dosing and tapering instructions must be followed closely.
- Care for complications: some puppies develop diarrhoea, fever or pneumonia, which need their own care. A puppy who lies in one spot all day needs to be turned regularly to prevent bedsores.
Severe cases may need hospital care, including intravenous fluids, nutritional support (sometimes a feeding tube) and stronger pain control than is possible at home. If your puppy is badly affected, your vet will talk you through the options and what is best for your puppy. Most puppies do not need this level of care.
The outlook for most puppies
There is reassuring news. Most dogs with mild to moderate HOD recover and go on to live a normal life. With appropriate veterinary care, many puppies start to feel more comfortable within days, although every puppy is different.
Relapse is possible until the long bones have finished growing. If an episode returns, pain management should be put in place again, so contact your vet rather than waiting it out.
In more severe cases, bone growth can sometimes be affected, which may influence posture and the ability to walk, run and play. This is one more reason to have limping checked early.
Where supplements fit
This is the part owners often ask about, so we want to be clear and careful.
Supplements are not a way to deal with HOD
The approach described by vets is pain control, exercise restriction where advised, and a balanced growth diet. A supplement cannot replace any of these, and no supplement should be given with the aim of dealing with HOD.
Your vet may ask you to stop them
If your puppy has suspected or diagnosed HOD, follow your vet's advice on supplements. They may recommend removing them. Please do not add or continue a supplement without asking first.
Diet balance matters in growing large breeds
An unbalanced diet is linked to HOD as a possible contributing factor. Adding extra products to a large breed puppy's bowl is something to talk through with your vet before you do it. A good large breed puppy food is designed to give the right balance already.
Joint supplements are mainly a topic for later life
The wider purpose of a joint supplement is to give nutritional support for mobility and joint comfort in adult and older dogs, alongside veterinary care. If you would like to understand how joints work in general, our complete guide to dog joint health is a good place to start. A supplement is not a stand-in for a diagnosis, pain relief or a proper diet.
About MedPaw Hip & Joint Chews Max
MedPaw Hip & Joint Chews Max is a daily soft chew and a complementary feed for dogs. It is not intended for HOD or for puppies with a bone-growth problem. If you have a growing large breed puppy, please speak to your vet before giving any supplement, ours included.
For dogs where a vet is happy for owners to consider one, the chew contains glucosamine, chondroitin, MSM, green-lipped mussel, hyaluronic acid and Boswellia serrata. It also provides omega-3 from green-lipped mussel and flax seed, plus vitamins C and E and zinc, and is made with rapeseed oil and glycerine.
The feeding guide is 1 chew a day up to 4kg, 2 for 5 to 17kg, and 2 to 3 for 18kg and over, doubled for the first three weeks. We recommend daily use for 2 to 3 months. There is a 60-day money-back guarantee, and Subscribe & Save is available.
Reading joint product labels
If you are comparing products for an adult dog, such as supplements for dogs with arthritis, it helps to know that they differ in format. Some are tablets, some are capsules, some are chewable tablets and some are soft chews. They also differ in which ingredients they list. For example, some list chondroitin and some do not, and some contain green-lipped mussel while others do not.
Check the label, think about what your dog will happily eat every day, and ask your vet if you are unsure. No single product suits every dog.
Practical advice for owners
- Feed a large breed puppy diet if you have a large or giant breed puppy, and ask your vet to check the food.
- Do not add supplements to a puppy's diet without your vet's agreement, especially in a breed prone to HOD.
- Never give human painkillers. Only dog-safe medicines prescribed by your vet are suitable.
- Follow exercise restrictions if your vet advises them during an episode.
- Follow dosing and tapering instructions exactly for any prescribed medicine, particularly steroids.
- Make resting comfortable. A puppy struggling to stand needs a soft, clean bed, and regular turning if they cannot get up.
- Keep a simple diary of limping, appetite, temperature concerns and any diarrhoea. It helps the vet, particularly if signs come and go.
- Expect possible relapses until your puppy has finished growing, and call your vet again if signs return.
When to see a vet
Book a visit promptly if a growing puppy, especially a large or giant breed, shows any of these:
- Persistent limping, particularly in a front leg
- Yelping or pulling away when a leg is touched
- Warm or swollen legs or joints
- Fever, loss of appetite or unusual tiredness
- Diarrhoea alongside any of the above
- Reluctance to walk, play or stand
Contact the vet urgently if your puppy cannot or will not get up, seems in severe pain, stops eating or is very unwell. Signs that return after an apparent recovery also need a vet's attention.
A calm way forward
HOD is painful and upsetting to watch, but most puppies with mild to moderate cases recover well with the right veterinary care. The most useful things you can do are get limping checked early, feed an appropriate large breed puppy diet and follow your vet's advice closely, including on supplements.
Once your dog is grown, and if your vet agrees, a complementary joint feed can be one small part of supporting comfort and mobility through adult and later life. It works alongside good veterinary care, never in place of it.
What is the best joint supplement for a dog with hypertrophic osteodystrophy?
HOD affects fast-growing large and giant breed puppies, and no supplement should be given with the aim of dealing with it. Management is led by your vet, usually pain control, exercise restriction where advised and a balanced large breed puppy diet. Your vet may ask you to stop supplements altogether, so please ask them before giving any product.
Can I give my puppy a joint supplement if they have HOD?
Please speak to your vet first. They may recommend removing supplements from the diet while your puppy is growing, as an unbalanced diet is described as a possible contributing factor. A complementary feed is not a substitute for pain relief, a diagnosis or a proper growth diet.
Is MedPaw Hip & Joint Chews Max suitable for a puppy with HOD?
No. It is a complementary feed for dogs and is not intended for HOD or for puppies with a bone-growth problem. If you have a growing large breed puppy, please speak to your vet before giving any supplement, ours included.
When might a joint supplement be worth considering for my dog?
Joint supplements are mainly a topic for adult and older dogs, to support mobility and joint comfort alongside veterinary care. If your dog has finished growing and your vet is happy for you to consider one, you can compare labels for the actives declared, the format and the guarantee. Always check with your vet if you are unsure.
How many MedPaw chews would an adult dog have at 20kg?
For dogs of 18kg and over the label says 2 to 3 chews a day, doubled for the first three weeks. A tub holds 60 chews, so at 2 a day it lasts 30 days, and at 3 a day it lasts 20 days. Daily use for 2 to 3 months is recommended. This is for adult dogs only, so check with your vet first if your dog has a health condition.
What should I do if my large breed puppy is limping?
Book a vet visit promptly, especially if the limp is persistent, in a front leg, or comes with heat, swelling, yelping, a lower appetite or tiredness. If your puppy cannot or will not get up, or seems in severe pain, contact your vet urgently. Limping in a growing puppy can have several causes, and only a vet can tell them apart, usually with an X-ray.


